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Evidence library

Verified study rows retain their model or population, endpoint, evidence tier, review date, and direct source.

Findings by compound

  1. 01RetatrutidePhase 1–24 verified studies
    The trial reported a −24.2% least-squares mean body-weight change in one study arm. ↗338 adults with obesity, or overweight plus a weight-related condition, without diabetesJastreboff et al., NEJM 2023Phase 1–2
  2. 02TirzepatidePhase 32 verified studies
    The trial reported a −20.9% mean body-weight change in one study arm. ↗2,539 adults with obesity, or overweight plus a complication, excluding diabetesJastreboff et al., NEJM 2022Phase 3
  3. 03BPC-157Animal3 verified studies
    The rat study reported tendon-to-bone healing findings. ↗Rat tendon-to-bone modelKrivic et al., Journal of Orthopaedic Research 2006Animal
  4. 04TB-500In vitro1 verified study
    The full-length thymosin beta-4 study reported endothelial migration and angiogenesis findings; the study does not establish those findings for the TB-500 fragment. ↗Human umbilical-vein endothelial cells and migration assaysMalinda, Goldstein & Kleinman, FASEB Journal 1997In vitro
  5. 05GHK-CuAnimal2 verified studies
    The rat study reported collagen and glycosaminoglycan increases across the tested conditions. ↗Rat wound chambersMaquart et al., Journal of Clinical Investigation 1993Animal
  6. 06IpamorelinAnimal1 verified study
    The pharmacology study characterized ipamorelin as a selective growth-hormone secretagogue. ↗Rat and swine pharmacologyRaun et al., European Journal of Endocrinology 1998Animal
  7. 07TesamorelinPhase 32 verified studies
    The trial reported a −15.2% CT visceral-adipose-tissue change compared with +5.0% for placebo. ↗412 HIV-positive adults with abdominal-fat accumulationFalutz et al., NEJM 2007Phase 3
  8. 08IGF-1 LR3In vitro1 verified study
    The cell-culture study reported proliferative stimulation in that conditioned-medium model. ↗Cultured postnatal rat lung fibroblastsPrice, Experimental Lung Research 2004In vitro
  9. 09MOTS-cAnimal1 verified study
    The study reported folate-cycle and AMPK findings alongside mouse metabolic observations. ↗Murine skeletal muscle, myotubes, and mouse diet/age modelsLee et al., Cell Metabolism 2015Animal
  10. 105-Amino-1MQAnimal1 verified study
    The study reported increased NAD+ and SAM in adipocytes and reduced adiposity in diet-induced-obese mice. ↗Differentiated adipocytes and diet-induced-obese miceNeelakantan et al., Biochemical Pharmacology 2018Animal
  11. 11NAD+In vitro3 verified studies
    The study characterized NAD dependence in a yeast Sir2 system. ↗Yeast Sir2 systemImai et al., Nature 2000In vitro
  12. 12Melanotan IIObservational4 verified studies
    The case report described melanoma temporally associated with reported exposure; the case report does not establish causality. ↗Single-patient case reportHjuler & Lorentzen, Dermatology 2014Observational